The O's are looking to pull away from the relegation places that are just 5 points below them.
Orient top scorer Scott McGleish is an injury doubt.
Midfielder Wayne Brown has joined Bristol Rovers on a one-month loan from Fulham and is expected to start.
Goalkeeper Mikkel Andersen will be available after extending his loan spell from Reading but Daryl Duffy will play no part after moving to Carlisle.
"We're looking to bounce back from a poor performance on Saturday," said Rovers boss Paul Trollope. With and without the ball we weren't good enough.
"We're going to go to Orient with a point to prove, both as individuals and as a group, that it wasn't the real us on Saturday.
"We've seen glimpses of what Dominic Blizzard can do but it's been a very stop-start season due to injuries and ill health."