Chris Dickson marked his debut by scoring twice against the Bees following his loan move from Charlton and should make his home debut.
Dickson is likely to partner Jo Kuffour in attack, with Darryl Duffy remaining on the bench.
Former Derby defender Steve Elliott is also expected to be in the bench, with the Pirates having conceded just one goal in their last four games.
One player that will definitely not feature is midfielder David Pipe, who has been suspended by the club after being arrested on suspicion of assault.
Brighton's injury problems have eased with Glenn Murray and Jake Wright available.
Striker Murray has been sidelined since mid-August after undergoing hernia surgery and left-back Wright has been out for six weeks with a hamstring injury.
But both players came through a behind-closed-doors practice match this week and should be in the squad.
Full-back Jim McNulty is also back in training following an ankle injury, although Saturday's game may come too soon.
On-loan midfielder Arron Davies rested a hamstring problem earlier in the week and is fit again, defender Colin Hawkins has recovered from a broken nose and back-up goalkeeper Graeme Smith returns on the bench following an ankle injury.
Sporting Life