Bristol Rovers hope skipper Stuart Campbell's promotion, after the sacking of boss Dave Penney on Monday, will inspire a change in fortune.
Cian Bolger or James Tunnicliffe could replace centre-back Jerel Ifil who serves a one-match ban.
Bristol Rovers have also recalled midfielder Harry Pell from his eye-catching loan spell at League Two Hereford.
New Rovers caretaker-player-manager Campbell will be thrown straight in at the deep end at Prenton Park - both as a manager and a player. But he says that he is not looking any further than the end of the season.
New Bristol Rovers caretaker-player-manager Stuart Campbell:
"Tranmere are a good side, so it is going to be difficult, but we will go there to try and win.
"I am 100% focussed on the next 12 games, and I am not thinking any further ahead than that at the moment.
"I am definitely going to continue playing. I do not want to give that up.
"Danny Coles and Byron Anthony will be helping me tomorrow night then I will sit down with the chairman towards the end of the week to see what will happen going forward."
Source: BBC Sport
Source: BBC Sport